Britt Reid (Seth Rogen), the heir to the largest newspaper fortune in Los Angeles, is a spoiled playboy who has been, thus far, happy to lead an aimless life. After his father (Tom Wilkinson) dies, Britt meets Kato (Jay Chou), a resourceful company employee. Realizing that they have the talent and resources to make something of their lives, Britt and Kato join forces as costumed crime-fighters to bring down the city’s most-powerful criminal, Chudnofsky (Christoph Waltz).
Cal Weaver is living the American dream. He has a good job, a beautiful house, great children and a beautiful wife, named Emily. Cal’s seemingly perfect life unravels, however, when he learns that Emily has been unfaithful and wants a divorce. Over 40 and suddenly single, Cal is adrift in the fickle world of dating. Enter, Jacob Palmer, a self-styled player who takes Cal under his wing and teaches him how to be a hit with the ladies.
Gerry is a talented but down-on-his-luck gambler whose fortunes begin to change when he meets Curtis, a younger, highly charismatic poker player. The two strike up an immediate friendship and Gerry quickly persuades his new friend to accompany him on a road trip to a legendary high stakes poker game in New Orleans. As they make their way down the Mississippi River, Gerry and Curtis manage to find themselves in just about every bar, racetrack, casino, and pool hall they can find, experiencing both incredible highs and dispiriting lows, but ultimately forging a deep and genuine bond that will stay with them long after their adventure is over.
When a globe-trotting, workaholic father trying to visit his daughter on a last minute layover in Los Angeles discovers that she’s disappeared, he forces her awkward, nervous ex-boyfriend, still nursing a broken heart, to help him find her over the course of one increasingly crazy night.
Longtime couple Henry and Dianne are afraid that if they finally tie the knot it would mean the end of their days as free-spirited urbanites. But a whirlwind night apart involving temptations from a duo of strangers will either make them realize why they are together in the first place or finally drive them apart forever.